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Published on: September 26, 2018
[Monitoring of cardiovascular risk factors in patients with diabetes type 2]
B Petrlová1, H Rosolová, J Simon
1II. interní klinika Lékarské fakulty UK a FN Plzen. nussbaumerova@fnplzen.cz
Insights
Cardiovascular risk factor control in type 2 diabetes patients is poor, with low achievement of blood pressure, glycemic, and lipid targets. Lifestyle changes are crucial for improving outcomes in this high-risk population.
Area of Science:
- Cardiology
- Endocrinology
- Public Health
Context:
- Type 2 diabetes mellitus (T2DM) significantly increases cardiovascular disease (CVD) risk.
- Effective management of modifiable risk factors is essential for secondary prevention in T2DM.
- This study assesses the control of key cardiovascular risk factors in a large cohort of T2DM patients.
Purpose:
- To evaluate the control of hypertension, dyslipidemia, and hyperglycemia in T2DM patients.
- To determine the proportion of patients achieving target values for blood pressure, glycemic control, and lipid profiles.
- To identify gaps in current pharmacotherapy and assess the potential for lifestyle interventions.
Summary:
- A cohort of 415 T2DM patients (mean age 66 years, 9.4 years diabetes history) with 95% hypertension was studied.
- Achievement rates for blood pressure, fasting glucose, HbA1c, and LDL-cholesterol targets were low (13-41% for various parameters).
- Only 13% met secondary prevention targets; statins were used by 60%, but hypolipidemic and antihypertensive therapies were suboptimal, highlighting potential for lifestyle modifications.
Impact:
- Current pharmacotherapy for hypertension and dyslipidemia in T2DM patients is largely unsatisfactory.
- There is a significant unmet need for improved risk factor management in T2DM.
- Lifestyle modifications represent a critical, underutilized strategy to enhance cardiovascular health in diabetic populations.
Abstract:
The control of basic cardiovascular risk factors was examined in a sample of 415 diabetes type 2 patients, aged 66 +/- 10 years, with a 9.4 +/- 8 years long history of diabetes, both genders represented proportionally; 95% of the sample were hypertensive. The recommended blood pressure value was achieved by 13% males and 17% females. Antihypertensive monotherapy was indicated in 40% of the sample. Renin-angiotensin-aldosteron system inhibitors were prescibed to 90% of the sample. The fasting glycaemia < or = 6 mmol/L were achieved in 10% males and 11% females; glycosilated hemoglobin < 4.5% in 20% males and 24% females; 60% of the sample had antidiabetic pharmacotherapy--44% males and 48% females used metformin. Total fasting plasma cholesterol < 4.5 mmol/L was achieved in 31% males and 23% females; LDL-cholesterol < 2.5 mmol/L was achieved in 31% males and 41% females. The target values for diabetics in secondary prevention of cardiovascular diseases or with subclinical atherosclerosis was achieved in 13% of the sample. Statins were prescribed in 60% of the sample, fibrates in 4%. Only 2 females achieved all the target values. Hypolipidemic and antihypertensive drug therapy is unsatisfactory; there is certainly a big potential in life style changes among the diabetic patients.
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