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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Micelles01:30

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
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Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

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Related Experiment Video

Updated: Jun 20, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Stabilized polymeric micelles by electrostatic interactions for drug delivery system.

Eui-Joon Cha1, Ju Eun Kim, Cheol-Hee Ahn

  • 1Research Institute of Advanced Materials (RIAM), Department of Materials Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-744, Republic of Korea.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|September 8, 2009
PubMed
Summary

Methoxy poly(ethylene glycol)-block-oligo(l-aspartic acid)-block-poly(epsilon-caprolactone) micelles were stabilized using calcium ions, enhancing their structural integrity and drug delivery capabilities. This ionic stabilization improves stability and sustained release of encapsulated paclitaxel.

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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

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Related Experiment Videos

Last Updated: Jun 20, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Polymeric micelles are promising for drug delivery.
  • Stabilization is crucial for sustained release and preventing dissociation.
  • Methoxy poly(ethylene glycol)-block-oligo(l-aspartic acid)-block-poly(epsilon-caprolactone) (mPEG-Asp-PCL) is a potential candidate for drug encapsulation.

Purpose of the Study:

  • To synthesize and characterize mPEG-Asp-PCL copolymer.
  • To investigate the stabilization of polymeric micelles using calcium cations.
  • To evaluate the drug loading, release kinetics, and stability of paclitaxel-loaded micelles.

Main Methods:

  • Synthesis of mPEG-Asp-PCL with a molecular weight of 8930 g/mol and M(w)/M(n) of 1.22.
  • Formation of polymeric micelles via dialysis and stabilization through electrostatic interactions with calcium cations.
  • Determination of critical micelle concentration (CMC) and evaluation of micelle dissociation.
  • Paclitaxel loading and encapsulation efficiency determination.
  • In vitro drug release studies at pH 7.4 in PBS with Tween 80.

Main Results:

  • Synthesized mPEG-Asp-PCL exhibited good characteristics for micelle formation.
  • Ionic stabilization with calcium cations significantly enhanced micelle structural stability, preventing dissociation at low concentrations.
  • Paclitaxel loading efficiency was 47.6%, with drug loading increasing micelle diameter.
  • Stabilized micelles demonstrated a sustained release profile over two weeks, contrasting with rapid release from non-stabilized micelles.
  • Non-stabilized micelles showed rapid drug release (approx. 65% in 24h), while stabilized micelles released approx. 45% in 24h, followed by a slow release.

Conclusions:

  • Ionic stabilization effectively enhances the stability of mPEG-Asp-PCL micelles, making them suitable for drug delivery applications.
  • The stabilized micelles offer a promising platform for developing long-circulating delivery systems for water-insoluble drugs like paclitaxel.
  • This approach provides a method for creating stable nanocarriers with controlled drug release characteristics.