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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Drugs that Stabilize Microtubules01:15

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Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
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Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Treatment Resistent Cancers02:56

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Updated: Jun 20, 2026

Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel
08:29

Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel

Published on: May 14, 2018

Paclitaxel and immune system.

Aqeel Javeed1, Muhammad Ashraf, Amjad Riaz

  • 1Department of Pharmacology & Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|September 8, 2009
PubMed
Summary
This summary is machine-generated.

Paclitaxel (PTX) is a chemotherapy drug that fights tumors by stabilizing microtubules. Beyond cancer, PTX also modulates immune cells, showing potential for autoimmune disorders and transplantation.

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Last Updated: Jun 20, 2026

Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel
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Live Imaging to Study Microtubule Dynamic Instability in Taxane-resistant Breast Cancers
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Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
07:55

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Published on: January 17, 2025

Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Background:

  • Chemotherapy, including Paclitaxel (PTX), is a primary treatment for various cancers.
  • PTX, a taxane, exhibits broad-spectrum anti-tumor activity, improving survival rates.
  • PTX functions by inhibiting cell division through excessive microtubule stabilization.

Purpose of the Study:

  • To review the immunomodulatory effects of Paclitaxel (PTX).
  • To explore PTX's impact on various immune cells.
  • To discuss PTX's therapeutic potential beyond oncology.

Main Methods:

  • Review of clinical and experimental findings on PTX's immunological effects.
  • Analysis of PTX's influence on macrophages, dendritic cells (DCs), NK cells, and T and B lymphocytes.
  • Examination of PTX's applications in autoimmune disorders and organ transplantation.

Main Results:

  • PTX demonstrates immunostimulatory effects against tumors.
  • PTX regulates lymphocyte activation.
  • PTX exhibits immunomodulatory traits impacting multiple immune cell types.

Conclusions:

  • Paclitaxel (PTX) possesses significant immunomodulatory properties.
  • PTX's effects on the immune system suggest broader therapeutic applications.
  • Further research into PTX's immune-modulating mechanisms is warranted for non-cancerous conditions.