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Leishmaniasis

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...

Antiprotozoal Agents

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

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Related Experiment Video

Updated: Jun 20, 2026

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

In vivo Imaging of Transgenic Leishmania Parasites in a Live Host

Published on: July 27, 2010

Imaging Leishmania development in their host cells.

Thierry Lang¹, Hervé Lecoeur, Eric Prina

¹Institut Pasteur, Département de Parasitologie et Mycologie, Unité d' Immunophysiologie et Parasitisme Intracellulaire, 75724 Paris cedex 15, France. thierry.lang@pasteur.fr

Trends in Parasitology

|September 8, 2009

Summary

This summary is machine-generated.

Advanced imaging techniques reveal how Leishmania parasites interact with host cells. Real-time monitoring of these parasites offers new insights into host-pathogen dynamics and disease progression.

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Area of Science:

Parasitology
Cell Biology
Infectious Diseases

Background:

Leishmania-host interactions are complex, occurring at multiple biological levels.
Understanding these dynamics is crucial for developing effective treatments.
Imaging technologies have evolved to study these interactions.

Purpose of the Study:

To review the application of imaging techniques in studying Leishmania-host interactions.
To highlight advancements in visualizing parasite behavior within the host.
To discuss future directions in imaging for Leishmania research.

Main Methods:

Review of conventional imaging techniques on fixed samples.
Use of transgenic Leishmania with fluorescent/bioluminescent reporters.
Application of whole-body imaging and intravital microscopy.

Main Results:

Conventional imaging provides static snapshots of parasite-host interactions.
Reporter-expressing parasites enable characterization of host niches.
Real-time imaging offers dynamic monitoring of parasites in vivo.
Intravital microscopy visualizes parasite behavior in their natural environment.

Conclusions:

Imaging technologies have significantly advanced the study of Leishmania-host interactions.
Real-time and in vivo imaging are essential for understanding parasite dynamics.
Future innovative imaging will further elucidate host-parasite interplay.