Primary renal lymphoma: report of three new cases and literature review
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Updated: Jun 20, 2026
Murine Bilateral Renal Lymphadenectomy
Published on: December 30, 2025
Fernando Vázquez Alonso1, Carolina Sánchez Ramos, Francisco Javier Vicente Prados
1Department of Urology, University Hospital Virgen de las Nieves, Granada, Spain. fernando.vazquez.alonso.sspa@juntadeandalucia.es
Objectives:
We report the cases of three patients with primary renal lymphoma. Diagnosis and subsequent treatment are discussed.
Methods:
The literature on the origin, epidemiology, clinical presentation, diagnosis, treatment and prognosis of primary renal lymphoma was reviewed.
Results:
The first patient was diagnosed after radical nephrectomy and subsequently was given six cycles of CVP (cyclophosphamide, vincristine, prednisone). The diagnosis of the second patient was established by renal biopsy, and the patient received six cycles of CHOP (cyclophosphamide, adriamycin, vincristine and predisone). The last patient had a lymphoma, secondary to immunosuppression, in a transplanted kidney. In this case transplant nephrectomy sufficed to cure the patient's lymphoma. All patients had B-cell non-Hodgkin lymphoma (an extrarenal origin was ruled out by bone marrow biopsy), and were disease-free 15 months, 7 months, and 6.5 years after diagnosis, respectively.
Conclusions:
Primary renal lymphoma is rare. Diagnosis is established by renal biopsy, although it often presents as a mass simulating renal cell cancer and diagnosis is obtained after radical nephrectomy. Treatment consists of chemotherapy (CHOP). associated with rituximab.
