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C-Reactive protein, a valuable predictive marker in chronic kidney disease
Georgi Abraham1, Varun Sundaram, Vivek Sundaram
1Department of Internal Medicine, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, Tamil Nadu, India. Abraham_georgi@yahoo.com
Summary
Inflammation and malnutrition markers like high C-reactive protein (CRP) and low serum albumin are common in predialysis chronic kidney disease (CKD) patients. These factors may synergize with other risks to promote atherosclerosis.
Area of Science:
- Nephrology
- Cardiology
- Clinical Nutrition
Background:
- Chronic kidney disease (CKD) patients often exhibit malnutrition and inflammation.
- These conditions are linked to increased cardiovascular risk, including atherosclerosis.
- Predialysis CKD represents a critical window for assessing these interrelated factors.
Purpose of the Study:
- To investigate the correlation between malnutrition and inflammation markers and atherosclerosis in predialysis CKD patients.
- To assess the prevalence of elevated inflammation and malnutrition markers in this population.
- To explore the relationship between these markers and carotid artery stenosis.
Main Methods:
- Observational study of 100 predialysis CKD patients.
- Assessed inflammation using highly sensitive C-reactive protein (hsCRP).
- Evaluated nutritional status via serum albumin and BMI; assessed carotid artery stenosis using Doppler ultrasonography; calculated estimated glomerular filtration rate (eGFR).
Main Results:
- High hsCRP levels (>6 mg/L) were observed in 67% of patients.
- Elevated hsCRP correlated with lower serum albumin levels (P < 0.01).
- Low serum albumin was associated with low hemoglobin, low eGFR, and diabetes mellitus; no statistically significant link found between markers and carotid stenosis.
Conclusions:
- Predialysis CKD patients exhibit significant inflammation and malnutrition.
- The interplay of inflammation and malnutrition may contribute to atherosclerosis beyond traditional risk factors.
- This study provides insights into these markers in predialysis CKD patients in developing countries.
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