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Updated: Jun 20, 2026
07:11
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
Synthesis of novel peptide linkers: simultaneous cyclization and labeling
Gajanan K Dewkar1, Pedro B Carneiro, Matthew C T Hartman
1Department of Chemistry and Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, Virginia 23298-0037, USA.
Organic Letters
|September 10, 2009
Abstract:
Synthesis of novel peptide linkers was accomplished by monocarboxylation of 1,3,5-tris(bomomethyl)benzene with a wide variety of carboxylic acids in the presence of diisopropylethylamine. These reagents can be used to simultaneously cyclize and label peptides containing two cysteines. Many labels are compatible with this method including lipids, fluorescent groups, and biotin.
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