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Identification of a new HLA-Cw*01 variant, Cw*0121, by sequence-based typing in a Chinese patient

Z Li1, H Zhang, S-Z Jin

  • 1Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen, Guangdong Province, China. sontony@yahoo.cn

Tissue Antigens
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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...