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Updated: Jun 20, 2026

The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans
Published on: April 28, 2022
A validation study of the alcohol dependence scale.
Suzanne R Doyle1, Dennis M Donovan
1Alcohol and Drug Abuse Institute, University of Washington, Seattle, 98105, USA. srdoyle@u.washington.edu
This study validates the three-factor structure of the Alcohol Dependence Scale (ADS), confirming its reliability in assessing alcohol dependence. A 12-item ADS measure also showed comparable validity to the full scale.
Area of Science:
- Psychiatry and Behavioral Science
- Clinical Psychology
- Addiction Research
Background:
- The Alcohol Dependence Scale (ADS) is a widely used measure for assessing alcohol dependence.
- Understanding the underlying factor structure of the ADS is crucial for its accurate interpretation and application.
- Previous research has suggested various factor structures for the ADS, necessitating further investigation.
Purpose of the Study:
- To comprehensively assess the underlying factor structure of the Alcohol Dependence Scale (ADS).
- To evaluate the concurrent validity of the total ADS and its derived subscales with alcohol dependence-related variables.
- To assess the validity of two proposed reduced-item ADS measures.
Main Methods:
- Factor analyses (exploratory and confirmatory) were conducted on ADS responses from participants in two large randomized clinical trials (COMBINE and Project MATCH).
- Participants met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for alcohol dependence.
- Validity coefficients were obtained to assess the relationship between ADS scores and other relevant measures.
Main Results:
- A correlated, three-factor solution was supported across samples, representing loss of behavioral control/heavy drinking, obsessive-compulsive drinking style, and withdrawal symptoms.
- The ADS total score and subscales demonstrated significant relationships with measures of dependence severity, craving, temptation, confidence in abstinence, drinking patterns, and negative alcohol-related consequences.
- The 12-item reduced ADS measure showed validity coefficients comparable to the full 25-item scale.
Conclusions:
- The findings support a three-factor structure for the ADS, confirming its reliability and validity in assessing alcohol dependence.
- The 12-item reduced ADS measure is a valid and potentially more efficient alternative to the full scale.
- These results enhance the utility of the ADS in clinical and research settings for evaluating alcohol dependence.
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