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Modeling drug release from PVAc/PVP matrix tablets.

F Siepmann¹, K Eckart, A Maschke

¹College of Pharmacy, JE 2491, Univ. Lille Nord de France, 3 rue du Professeur Laguesse, 59006 Lille, France. juergen.siepmann@univ-lille2.fr

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|September 10, 2009

Summary

A new mathematical model accurately predicts drug release from Kollidon SR matrix tablets. This model, validated experimentally, aids in optimizing advanced drug delivery systems for desired release profiles.

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Area of Science:

Pharmaceutical Sciences
Materials Science
Chemical Engineering

Background:

Kollidon SR matrix tablets are utilized for advanced drug delivery.
Understanding drug release mechanisms is crucial for optimizing these systems.

Purpose of the Study:

To develop and validate a mechanistic mathematical theory for drug release from diprophylline-loaded Kollidon SR matrix tablets.
To quantitatively predict the impact of tablet dimensions on drug release kinetics.

Main Methods:

Preparation and in vitro characterization of diprophylline-loaded Kollidon SR matrix tablets.
Drug release studies in HCl and phosphate buffer (pH 7.4).
Monitoring of tablet dimensional and mass changes.
Development and application of a mathematical model incorporating radial and axial mass transport.

Main Results:

Experimental data showed good agreement with the proposed mathematical theory.
Drug diffusion with constant diffusivity was identified as the primary mass transport mechanism.
The model accurately predicted the influence of initial tablet dimensions on drug release.

Conclusions:

The validated mathematical theory provides a practical tool for optimizing drug release profiles in Kollidon SR matrix tablets.
This approach can significantly facilitate the development of advanced drug delivery systems.