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Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
Published on: June 12, 2021
Short- and long-term outcomes of percutaneous coronary interventions in patients with severe left ventricular
Imad Sheiban1, Claudio Moretti, Giuseppe Biondi Zoccai
1Interventional Cardiology, Division of Cardiology, University of Torino, San Giovanni Battista Hospital, Torino, Italy.
Insights
Percutaneous coronary intervention (PCI) offers excellent procedural success for patients with coronary artery disease and severe left ventricular dysfunction. Long-term outcomes show acceptable morbidity and mortality, making PCI a viable option.
Area of Science:
- Cardiology
- Interventional Cardiology
Background:
- Severe left ventricular dysfunction (EF < 30%) poses high risk for revascularization procedures.
- Coronary artery disease (CAD) with impaired left ventricular function requires careful treatment strategies.
Purpose of the Study:
- To assess the immediate and long-term results of percutaneous coronary intervention (PCI) in patients with CAD and severe left ventricular dysfunction.
- To evaluate the safety and efficacy of PCI in a high-risk patient cohort.
Main Methods:
- Seventy-eight patients with CAD and EF < 30% underwent PCI.
- Analysis of procedural success, adverse events, and long-term follow-up outcomes.
- Identification of independent predictors for mortality and major adverse cardiac events (MACE).
Main Results:
- High procedural success rate (97.8%) with low in-hospital adverse events (7.8%).
- At a mean follow-up of 25 months, event-free survival was 55%, with 27.6% requiring repeat revascularization.
- Female gender, diabetes, myocardial infarction, and treated vessel count predicted adverse outcomes.
Conclusions:
- PCI is a safe and effective option for symptomatic patients with CAD and severe left ventricular dysfunction.
- The procedure demonstrates excellent procedural success and acceptable long-term morbidity and mortality.
Aims:
Poor left ventricular function is considered a high risk condition for performing either percutaneous (PCI) or surgical revascularisation. The aim of this study was to evaluate immediate and long term results of PCI in patients with coronary artery disease (CAD) and severe left ventricular dysfunction (EF < 0.30).
Methods And Results:
Seventy-eight consecutive patients with CAD and severe left ventricular dysfunction (EF < 30%) were selected. The majority of these patients (87%) had multivessel disease. Coronary angioplasty procedure was mainly motivated by angina associated with clinical manifestation of heart failure (54%). Total number of treated vessels was 181, and a total of 203 stents were implanted (2.6 stent/patient). Procedural success was achieved in 77 patients (97.8%). The total procedural and in-hospital adverse event rate was 7.8%. Mean follow-up period (FU) was 25+/-6 months. Event-free survival rate at the end of FU was 55%; repeat revascularisation was performed in 21 patients (27.6%). Female gender, diabetes, new acute myocardial infarction and number of treated vessels were independent predictors for death and combined mayor adverse cardiac events (MACE) during the follow-up.
Conclusions:
In symptomatic patients with CAD and severe left ventricular dysfunction, PCI can be performed with excellent procedural outcome and acceptable long-term morbidity and mortality.
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