[Microflora dynamics in purulent skin wound in rats after ozonized perftorane applications]

Area of Science:

• Wound healing research
• Microbiology
• Ozone therapy

Background:

• Infected wounds pose significant clinical challenges.
• Effective antimicrobial strategies are crucial for wound management.
• Perftorane is a potential wound irrigant.

Purpose of the Study:

• To evaluate the efficacy of ozonated perftorane in treating contaminated skin defects.
• To compare ozonated perftorane with non-ozonated perftorane and physiological solution.
• To investigate the impact of ozonated perftorane on microbial load and wound healing parameters.

Main Methods:

• Wistar rats with experimentally induced, contaminated skin defects were used.
• Three groups received irrigations with ozonated perftorane, non-ozonated perftorane, or physiological solution.
• Microbial colony counts, granulation tissue formation, and epithelization were assessed over 30 days.

Main Results:

• Ozonated perftorane significantly reduced mean microorganism counts from day 15.
• Granulation tissue growth and epithelization were accelerated in the ozonated perftorane group.
• These effects were superior to those observed with physiological solution and non-ozonated perftorane.

Conclusions:

• Ozonated perftorane demonstrates superior antimicrobial and wound healing properties.
• Ozone's benefits extend beyond direct bactericidal action to include local immune activation.
• Ozonated perftorane represents a promising therapeutic agent for contaminated wound management.