Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Halothane anesthesia causes active flow-independent pulmonary vasoconstriction.

B B Chen1, D P Nyhan, D M Fehr

  • 1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.

The American Journal of Physiology
|July 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The method of determination for trichloroaniline in the air of workplace by liquid chromatography with solvent elution].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2025
Same author

[Clinical management of thrombocytopenia in cirrhosis].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·2024
Same author

[Investigation of a cluster epidemic of COVID-19 in Ningbo].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2020
Same author

[A multicenter investigation and analysis on anemia in lymphoma patients in Shanghai].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2020
Same author

[Giant teratoma of nasopharynx with cleft palate and lingual hamartoma in the newborn: a case report].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2019
Same author

[Prevalence of allergy in children with acute rhinosinusitis].

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery·2018
Same journal

Blood coagulation in fish.

The American journal of physiology·2011
Same journal

Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

The American journal of physiology·2010
Same journal

The inactivation of placental toxin by human serum.

The American journal of physiology·2010
Same journal

Adrenal function following ovariectomy in the rat.

The American journal of physiology·2010
Same journal

Capillary permeability; perfusion of frog and guinea pig hind limbs.

The American journal of physiology·2010
Same journal

Evaluation of protective measures against sunburn.

The American journal of physiology·2010
See all related articles

Halothane anesthesia causes pulmonary vasoconstriction in dogs, independent of blood flow. This effect is not mediated by common neurohumoral pathways or cyclooxygenase metabolites.

Area of Science:

  • Physiology
  • Anesthesiology
  • Cardiovascular Research

Background:

  • Pulmonary vascular pressure-flow (P/Q) relationships are crucial for understanding pulmonary circulation.
  • Halothane anesthesia is widely used but its specific effects on the pulmonary vasculature require detailed investigation.

Purpose of the Study:

  • To assess alterations in the pulmonary P/Q relationship during halothane anesthesia compared to the conscious state.
  • To determine the mechanisms underlying halothane-induced pulmonary vasoconstriction.

Main Methods:

  • Utilized multipoint pulmonary vascular pressure-flow (P/Q) plots in dogs.
  • Investigated effects of halothane anesthesia (approx. 1.2% end-tidal) on pulmonary circulation.
  • Administered interventions including alpha-adrenoreceptor block, ACE inhibition, vasopressin receptor block, and cyclooxygenase inhibition.

Related Experiment Videos

Main Results:

  • Halothane anesthesia induced active, flow-independent pulmonary vasoconstriction (P < 0.01) in dogs.
  • Systemic arterial pressure and cardiac output were decreased by halothane (P < 0.01).
  • Pulmonary vasoconstriction was not significantly attenuated by tested pharmacological interventions or compared to pentobarbital anesthesia.

Conclusions:

  • Halothane anesthesia causes significant pulmonary vasoconstriction independent of blood flow.
  • The observed vasoconstriction is not mediated by reflex neurohumoral activation or cyclooxygenase metabolites.
  • The effects are specific to halothane and not solely due to general anesthesia or controlled ventilation.