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Chemical mediators in hypersensitivity reactions
T Nagakura1, M Ebisawa, D C Reason
1Division of Allergy, National Children's Medical Research Center, Tokyo, Japan.
Acta Paediatrica Japonica : Overseas Edition
|April 1, 1990
Abstract:
The study of chemical mediators is essential in clarifying the mechanism of hypersensitivity reactions. Recent advances in this field have been made particularly with the arachidonic acid metabolites, several of which strongly contract smooth muscle, attract granulocytes to inflammatory foci and lead to increased vascular permeability. These functions play a crucial role in allergic reactions. Furthermore these mediators might work to modulate the intracellular network which mediates the complicated inflammatory process of hypersensitivity reactions.