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Related Concept Videos

Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...

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Related Experiment Video

Updated: Jun 20, 2026

A New Murine Model of Endovascular Aortic Aneurysm Repair
08:51

A New Murine Model of Endovascular Aortic Aneurysm Repair

Published on: July 7, 2013

EVAR for ruptured AAAs -- Do we need randomized controlled trials?

I M NORDON1, R J D HINCHLIFFE, P J HOLT

  • 1St George's Vascular Institute, St James' Wing, St George's Hospital, London, UK. inordon@sgul.ac.uk

The Journal of Cardiovascular Surgery
|September 11, 2009
PubMed
Summary
This summary is machine-generated.

Emergency endovascular abdominal aortic aneurysm (EVAR) repair shows promise for ruptured AAAs, but a randomized controlled trial (RCT) comparing it to open surgery is debated. Evidence is growing for EVAR in selected patients.

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Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
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Last Updated: Jun 20, 2026

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07:21

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

Published on: September 28, 2015

Area of Science:

  • Vascular Surgery
  • Endovascular Interventions
  • Aortic Aneurysm Management

Background:

  • Endovascular abdominal aortic aneurysm (EVAR) repair is standard for elective cases.
  • EVAR application for ruptured AAAs (rAAA) is evolving with a developing evidence base.
  • No randomized controlled trial (RCT) has confirmed EVAR superiority over open repair for rAAA.

Purpose of the Study:

  • To review the current evidence for emergency EVAR (eEVAR) in managing ruptured abdominal aortic aneurysms (rAAA).
  • To discuss the arguments for and against conducting an RCT comparing eEVAR and open surgery for rAAA.
  • To detail ongoing and planned clinical trials for optimal rAAA management.

Main Methods:

  • Literature review of current evidence on eEVAR for rAAA.
  • Analysis of the debate surrounding the necessity, ethics, and feasibility of an RCT for eEVAR versus open repair.
  • Summary of existing and prospective clinical trials in rAAA management.

Main Results:

  • EVAR has been used for rAAA for over a decade, with increasing evidence in selected patients.
  • The role and feasibility of an RCT for eEVAR versus open repair remain subjects of debate.
  • Several clinical trials are underway to further define the optimal treatment strategy for rAAA.

Conclusions:

  • While EVAR is increasingly used for rAAA, its superiority over open repair requires further robust evidence, ideally from RCTs.
  • Ethical and practical considerations challenge the design and execution of such RCTs.
  • Ongoing trials aim to provide definitive evidence for the best management of ruptured abdominal aortic aneurysms.