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Imaging chiroptical artifacts.

John H Freudenthal1, Eva Hollis, Bart Kahr

  • 1Department of Chemistry, University of Washington, Seattle, Washington, USA.

Chirality
|September 11, 2009
PubMed
Summary
This summary is machine-generated.

Systematic artifacts in circular dichroism (CD) measurements, often dismissed, can reveal valuable information about material structure. These artifacts in D-sorbitol spherulites arise from crystal optics, not chiroptical properties, defining mesoscale structure.

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Area of Science:

  • Materials Science
  • Optics
  • Crystallography

Background:

  • Circular dichroism (CD) measurements can be affected by artifacts from mixed linear anisotropies in anisotropic media.
  • These artifacts are typically viewed as measurement errors but may contain useful structural information.

Purpose of the Study:

  • To investigate the origin of apparent chiroptical signals observed at the boundaries of polycrystalline D-sorbitol spherulites.
  • To demonstrate that these signals are artifacts of linear anisotropies, not true chiroptical effects.

Main Methods:

  • Analysis of polycrystalline D-sorbitol spherulites using Mueller matrix microscopy.
  • Acquisition and interpretation of differential polarization images.

Main Results:

  • Strong apparent optical rotation and CD signals were observed at the boundaries between D-sorbitol spherulites.
  • These signals were attributed to the interaction of linear anisotropies within the polycrystalline structure.
  • The observed signals did not originate from chiroptical properties of the material.

Conclusions:

  • Apparent chiroptical artifacts in anisotropic media can arise from crystal-optical effects related to linear anisotropies.
  • These artifacts are not merely measurement errors but provide insights into the mesoscale structure of polycrystalline materials.
  • Systematic analysis of such artifacts can enhance understanding of material properties and organization.