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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...

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Related Experiment Video

Updated: Jun 20, 2026

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
13:21

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Published on: June 16, 2017

Chronic lymphocytic leukemia: interplay between noncoding RNAs and protein-coding genes.

George A Calin1, Carlo M Croce

  • 1Departments of Experimental Therapeutics and Cancer Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.

Blood
|September 12, 2009
PubMed
Summary

MicroRNAs (miRNAs) and noncoding RNAs (ncRNAs) play crucial roles in chronic lymphocytic leukemia (CLL) development and progression. Understanding these molecules offers new diagnostic, prognostic, and therapeutic avenues for CLL patients.

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Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), are increasingly recognized for their role in cancer pathogenesis.
  • Dysregulation of miRNA expression is implicated in the initiation, progression, and dissemination of various cancers, including leukemias.
  • In chronic lymphocytic leukemia (CLL), miRNAs can function as either tumor suppressors or oncogenes.

Purpose of the Study:

  • To elucidate the roles of miRNAs and ultraconserved ncRNAs in chronic lymphocytic leukemia (CLL).
  • To propose a novel model for CLL predisposition and progression involving ncRNAs.
  • To identify potential diagnostic, prognostic, and therapeutic targets in CLL.

Main Methods:

  • Review of current literature on miRNA and ncRNA function in CLL.
  • Analysis of gene expression data and regulatory networks.
  • Development of a conceptual model for ncRNA involvement in CLL pathogenesis.

Main Results:

  • miRNAs are significantly involved in the pathogenesis of CLL through the dysregulation of cancer genes.
  • ncRNAs contribute to both the predisposition and progression of CLL.
  • miRNAs exhibit dual roles as tumor suppressors or oncogenes in cancer development.

Conclusions:

  • Understanding ncRNA and miRNA roles in CLL provides insights into gene regulation.
  • These molecules represent promising biomarkers for improved diagnosis and prognosis in CLL.
  • Targeting ncRNAs and miRNAs may offer novel therapeutic strategies for CLL patients.