Related Experiment Video
Updated: Jun 20, 2026
05:10
Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Automatic indexing in a drug information portal
Saoussen Sakji1, Catherine Letord, Badisse Dahamna
1CISMeF, Rouen University Hospital, Rouen. Sakji.Saoussen@chu-rouen.fr
Studies in Health Technology and Informatics
|September 12, 2009
Summary
This study developed a bilingual Drug Information Portal (DIP) using automatic Anatomical Therapeutic Chemical (ATC) classification for improved drug information retrieval. The ATC indexing achieved 76% relevance, enhancing access to drug substance, action, and therapeutic characteristics.
Area of Science:
- Medical Informatics
- Pharmacology
- Information Science
Background:
- Developing comprehensive drug information resources is crucial for healthcare professionals.
- Existing drug information portals often lack multilingual support and sophisticated indexing.
- The need for efficient retrieval of drug characteristics, including therapeutic and chemical properties, is paramount.
Purpose of the Study:
- To create a bilingual (French/English) Drug Information Portal (DIP).
- To implement automatic Anatomical Therapeutic Chemical (ATC) classification for enhanced drug indexing.
- To improve the retrieval of pertinent information on drug substances, target organs/systems, and therapeutic/chemical characteristics.
Main Methods:
- Leveraged the CISMeF portal infrastructure for cataloging and indexing health information.
- Developed specific functionalities for the DIP, incorporating drug-specific terminologies.
- Utilized the ATC classification system for automatic indexing of DIP resources.
Main Results:
- The Drug Information Portal (DIP) was developed through collaboration with VIDAL Company.
- The DIP is designed to streamline user information retrieval processes.
- Automatic ATC indexing yielded relevant results in 76% of evaluated cases.
Conclusions:
- Employing a multi-terminological context and appropriate drug indexing (codes/terms) is vital for effective information storage and retrieval.
- The developed ATC automatic indexing approach shows significant promise in the drug information field.
- Future efforts will focus on enhancing the accuracy of the ATC indexing methodology.
Related Concept Videos
01:26Drug Discovery: Overview
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
01:15Drug Dosage Regimen: Overview
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
01:17Drug Nomenclature
During the development of a new pharmaceutical, the manufacturer initially assigns a code name to the drug. Once approved, the drug receives a United States Adopted Name (USAN)—a generic, nonproprietary designation. Upon being listed in the United States Pharmacopeia, this nonproprietary name becomes the drug's official name. Additionally, the manufacturer assigns a proprietary name or trademark, which serves as the brand name under which the drug is marketed. It is worth noting that the same...
01:16Drug Biotransformation: Overview
Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
01:28Drug Biotransformation: Overview
Biotransformation, also known as drug metabolism, is a vital physiological process that chemically alters drugs, facilitating their elimination from the body and terminating their action. This process involves two main phases: phase I and phase II reactions. Phase I reactions, including oxidation, reduction, and hydrolysis, introduce or unmask polar functional groups on the drug molecule, thereby increasing its water solubility. By enhancing water solubility, the drug becomes more hydrophilic...
01:17Drug Absorption: Overview
The process of drug absorption signifies the transition of a drug from its site of administration into the plasma. This process is influenced by various factors, including the route of administration, the anatomy of the absorption site, the mechanism of absorption, gut motility, and the drug's physicochemical properties.
When drugs are injected intravenously, they directly enter the systemic circulation. Alternatively, orally administered drugs navigate through the gastrointestinal (GI) tract.
When drugs are injected intravenously, they directly enter the systemic circulation. Alternatively, orally administered drugs navigate through the gastrointestinal (GI) tract.