Related Experiment Video
Updated: Jun 20, 2026

Ion Exchange Chromatography (IEX) Coupled to Multi-angle Light Scattering (MALS) for Protein Separation and Characterization
Published on: April 5, 2019
Capillary electrophoretic enantioseparation of m-nisoldipine using two different beta-cyclodextrins
Dezhi Kong1, Wei Yang, Kunfeng Duan
1Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, PR China.
Abstract:
The methods for the enantioseparation of m-nisoldipine, a new 1,4-dihydropyridine calcium ion antagonist, were developed. The elaborated methods of m-nisoldipine enantiomers separation were successfully performed using an anionic CD-sulfobutyl ether-beta-CD (SBE-beta-CD) or carboxymethyl-beta-CD as chiral selector. However, the results indicated that SBE-beta-CD was a better chiral selector for enantioseparation of the neutral m-nisoldipine. Furthermore, comparing the two SBE-beta-CDs, the derivative with a higher degree of substitution (DS) of 7.0 induced better enantioresolution than the one with low DS (4.0). In addition, possible chiral recognition mechanisms of dihydropyridines were discussed.
More Related Videos
10:10Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
09:12Selection of Transporter-Targeted Inhibitory Nanobodies by Solid-Supported-Membrane (SSM)-Based Electrophysiology
Published on: May 3, 2021
Related Concept Videos
Capillary Electrophoresis: Applications
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...
Ion-Exchange Chromatography
Electrophoresis: Overview
There...
Size-Exclusion Chromatography
Silica particles offer advantages such as rigidity,...
Capillary Electrophoresis: Instrumentation
Dialysis