Related Experiment Video
Updated: Jun 20, 2026

Isolation and Expansion of Adult Canine Hippocampal Neural Precursors
Published on: November 29, 2016
Brain aging in dogs: parallels with human brain aging and Alzheimer's disease
1Institute for Brain Aging and Dementia, University of California, Irvine, CA 92612, USA.
Abstract:
Differentiating normal from pathologic aging is a challenge to veterinarians treating geriatric patients and to clinicians diagnosing Alzheimer's disease. Part of the difficulty stems from the lack of a biological marker. Dogs and humans develop similar cognitive dysfunction with age, and a subset of individuals develop severe impairments. Similar neuropathology also develops in the brains of elderly humans, individuals with Alzheimer's disease, and dogs. Both species develop senile plaque neuropathology, with more extensive plaque accumulation associated with severe cognitive impairments. This article discusses similarities in the clinical features and development of neuropathology with age in both dogs and humans and provides a discussion of treatment options.
More Related Videos
08:29Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
Published on: December 18, 2016
09:45Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
Published on: March 22, 2016
Related Concept Videos
Alzheimer Disease l: Introduction
Alzheimer Disease ll: Pathophysiology
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Dementia l: Introduction
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
The Effect of Aging on Tissues