Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...
Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electrically Tunable Heliconical Smectic Superstructure in Polar Fluids.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Long-Term Outcomes in Patients With Recurrent Ovarian Cancer and Exceptional Response to PARP Inhibitors.

JAMA oncology·2026
Same author

Phase-Transition-Induced Fluorescence Changes in a Calamitic Liquid Crystal With an AIEgen Mesogen.

Chemistry, an Asian journal·2026
Same author

Push-Pull Biphenyl Liquid Crystals Enabling Low-Voltage-Driven Light-Emitting Devices.

Chemistry, an Asian journal·2026
Same author

<i>In vivo</i> dynamic optical coherence tomography of human skin with hardware- and software-based motion correction.

Biomedical optics express·2026
Same author

Bioequivalence of Generic Semi-solid Topical Dermatological Drug Products: Scientific and Regulatory Perspective from Japan's 2025 Guidelines.

Therapeutic innovation & regulatory science·2026

Related Experiment Video

Updated: Jun 20, 2026

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images
08:02

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images

Published on: November 15, 2024

Nonlinear regression-based method for pseudoenhancement correction in CT colonography.

Baigalmaa Tsagaan1, Janne Näppi, Hiroyuki Yoshida

  • 1Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

Medical Physics
|September 15, 2009
PubMed
Summary
This summary is machine-generated.

A new nonlinear regression-based method corrects pseudoenhancement in CT colonography (CTC) data caused by tagging agents. This improves polyp detection accuracy and size measurement, enhancing diagnostic reliability in CTC examinations.

More Related Videos

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities
07:13

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities

Published on: October 27, 2023

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
06:49

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer

Published on: February 10, 2023

Related Experiment Videos

Last Updated: Jun 20, 2026

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images
08:02

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images

Published on: November 15, 2024

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities
07:13

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities

Published on: October 27, 2023

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
06:49

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer

Published on: February 10, 2023

Area of Science:

  • Medical Imaging
  • Radiology
  • Gastroenterology

Background:

  • CT colonography (CTC) uses contrast tagging agents to distinguish bowel contents from colonic structures.
  • Tagging agents can cause pseudoenhancement, artificially increasing CT numbers of adjacent tissues.
  • Pseudoenhancement complicates differentiation of colonic structures and accurate polyp assessment in CTC.

Purpose of the Study:

  • To develop and validate a nonlinear regression-based (NLRB) method for pseudoenhancement correction in CTC.
  • To improve the accuracy of polyp detection and size measurement in CTC examinations.

Main Methods:

  • Developed an NLRB method for local, image-based pseudoenhancement correction of CTC data.
  • Calibrated correction parameters using anthropomorphic phantoms with correlated CT data.
  • Employed adaptive multiresolution registration and a virtual tagging scheme for surface correlation.
  • Optimized the NLRB method using the Nelder-Mead downhill simplex algorithm.

Main Results:

  • The NLRB correction significantly reduced differences in CT numbers between tagged and untagged phantom regions.
  • Post-correction measurements of simulated and real polyp sizes showed no significant difference compared to untagged or colonoscopy data.
  • Automated polyp detection accuracy increased from 60% to 96% with reduced false positives after NLRB correction.

Conclusions:

  • The proposed NLRB method effectively corrects pseudoenhancement in CTC data.
  • This correction significantly improves polyp size measurement accuracy and automated detection rates.
  • The NLRB method offers substantial benefits for clinical CTC examinations.