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Updated: Jun 20, 2026

Quantitative Immunofluorescence to Measure Global Localized Translation
Published on: August 22, 2017
Hot topics in aging research: protein translation, 2009
Brian K Kennedy1, Matt Kaeberlein
1Departments of Biochemistry, University of Washington, Seattle, WA 98195, USA. bkenn@u.washington.edu
Abstract:
In the last few years, links between regulation of mRNA translation and aging have been firmly established in invertebrate model organisms. This year, a possible relationship between mRNA translation and aging in mammals has been established with the report that rapamycin increases lifespan in mice. Other significant findings have connected translation control with other known longevity pathways and provided fodder for mechanistic hypotheses. Here, we summarize advances in this emerging field and raise questions for future studies.
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