Pharmaceutical trace analysis in aqueous environmental matrices by liquid chromatography-ion trap tandem mass
Tânia Vieira Madureira1, Juliana Cristina Barreiro, Maria João Rocha
1Health Sciences Research Center of the Superior Institute Health Sciences-North, Gandra, Paredes, Portugal.
Abstract:
An analytical method based on solid-phase extraction followed by liquid chromatography tandem mass spectrometry with an ion trap analyser was developed and validated for the quantification of a series of pharmaceutical compounds with distinct physical-chemical characteristics in estuarine water samples. Method detection limits were between 0.03 and 16.4 ng/L. The sensitivity and the accuracy obtained associated with the inherent confirmatory potential of ion trap tandem mass spectrometry (IT-MS/MS) validates its success as an environmental analysis tool. Two MS/MS transitions were used to confirm compound identity. Almost all pharmaceuticals were detected at ng/L level in at least one sampling site of the Douro River estuary, Portugal.
Related Concept Videos
High-Performance Liquid Chromatography: Types of Detectors
Mass Spectrometry: Complex Analysis
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
Peptide Identification Using Tandem Mass Spectrometry
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
Ion-Exchange Chromatography
MALDI-TOF Mass Spectrometry
Matrix-Assisted Laser Desorption Ionization (MALDI)

