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Published on: September 8, 2021
Impact of human serum albumin on oritavancin in vitro activity against Staphylococcus aureus
Francis F Arhin1, Geoffrey A McKay, Sylvain Beaulieu
1Anti-Infective Unit, The Medicines Company, St. Laurent, Quebec H4S 2A1, Canada. farhin.arhin@themedco.com
Abstract:
Human serum albumin (HSA) did not affect oritavancin MICs against non-vancomycin-intermediate Staphylococcus aureus (non-VISA) strains. In time-kill assays, oritavancin bactericidal activity in the presence of HSA was significantly more rapid than comparators against non-VISA strains. HSA increased oritavancin MICs by 4-fold for VISA strains, reflective of reduced oritavancin activity in time-kill assays with HSA.
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