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Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction

Maryline Couette1, Marie-Françoise Boisse, Patrick Maison

  • 1INSERM, Unite U955, Team 1, Creteil F-94010, France.

Journal of Inorganic Biochemistry
|September 15, 2009
PubMed

Insights

Macrophagic myofasciitis (MMF), linked to persistent aluminum hydroxide from vaccines, causes significant cognitive dysfunction. This impairment affects memory and executive functions, independent of pain or fatigue.

Area of Science:

  • Immunology
  • Neurology
  • Toxicology

Background:

  • Macrophagic myofasciitis (MMF) is an emerging condition linked to aluminum hydroxide persistence post-vaccination.
  • Patients often report arthralgias, chronic fatigue, and cognitive difficulties.

Purpose of the Study:

  • To prospectively delineate MMF-associated cognitive dysfunction (MACD) using a comprehensive neuropsychological test battery.
  • To compare cognitive function in MMF patients versus controls with arthritis and chronic pain.

Main Methods:

  • A battery of neuropsychological tests was administered to MMF patients and controls.
  • Cognitive performance was assessed, focusing on memory, executive functions, and auditory processing.

Main Results:

  • MMF patients exhibited pronounced and specific cognitive impairments compared to controls.
  • Deficits were observed in visual and verbal memory, attention, working memory, planning, and left ear extinction.
  • Cognitive deficits did not correlate with pain, fatigue, depression, or disease duration.

Conclusions:

  • Long-term persistence of vaccine-derived aluminum hydroxide, as indicated by MMF, is associated with cognitive dysfunction.
  • MMF-associated cognitive dysfunction is distinct from symptoms of chronic pain, fatigue, and depression.

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