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Related Experiment Videos

Homeogene expression patterns and chromosomal imprinting.

S J Gaunt1, P B Singh

  • 1Department of Molecular Embryology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK.

Trends in Genetics : TIG
|July 1, 1990
PubMed
Summary
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Mouse and Drosophila homeogenes show similar chromosomal organization and embryonic expression patterns. This suggests a shared chromosomal imprinting mechanism for maintaining homeogene expression memory during development.

Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • Homeobox-containing genes (homeogenes) exhibit conserved chromosomal organization in different species.
  • A collinear relationship exists between homeogene order on the chromosome and their anterior-to-posterior expression domains in developing embryos of both mouse and Drosophila.

Purpose of the Study:

  • To investigate the potential common mechanisms underlying homeogene regulation in embryonic development.
  • To explore the role of chromosomal imprinting in maintaining cellular memory of homeogene expression patterns.

Main Methods:

  • Comparative analysis of homeogene organization and expression patterns in mouse and Drosophila embryos.
  • Investigation of potential epigenetic mechanisms, specifically chromosomal imprinting.

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Main Results:

  • Demonstrated a strict correspondence between gene order (3' to 5') and expression domains (anterior to posterior) for homeogenes in both species.
  • Identified similarities in homeogene regulation that suggest a conserved regulatory mechanism.

Conclusions:

  • The conserved collinearity and expression patterns of homeogenes in mouse and Drosophila point towards a shared regulatory mechanism.
  • Chromosomal imprinting may be a common mechanism employed by these species to retain cellular memory of homeogene expression during embryonic development.