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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
A mouse model for studying dengue virus pathogenesis and immune response
Katherine L Williams1, Simona Zompi, P Robert Beatty
1Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, California 94720-7354, USA.
Annals of the New York Academy of Sciences
|September 16, 2009
Summary
The AG129 mouse model is crucial for dengue virus research, allowing infection by all serotypes and enabling studies on immunity, pathogenesis, and interventions. This model supports replication and immune responses comparable to human dengue disease.
Area of Science:
- Virology
- Immunology
- Infectious Diseases
Background:
- A critical need exists for small animal models to advance dengue virus (DENV) research.
- Existing models often fail to replicate key aspects of human DENV infection.
Purpose of the Study:
- To review the development and characterization of the AG129 mouse model for DENV infection.
- To highlight the AG129 model's utility in studying host immunity, pathogenesis, and therapeutic development.
Main Methods:
- Characterization of the AG129 mouse model's susceptibility to all four DENV serotypes.
- Assessment of DENV replication in relevant cell and tissue types within the AG129 model.
- Evaluation of antibody-mediated protection and enhancement of DENV infection in AG129 mice.
Main Results:
- The AG129 model permits infection by all four DENV serotypes.
- DENV replication in AG129 mice mirrors patterns observed in human infections.
- The model allows for the study of both protective and enhancing effects of antibodies on DENV infection.
Conclusions:
- The AG129 mouse model is a valuable tool for in vivo dengue virus research.
- It facilitates testing hypotheses derived from epidemiological and in vitro studies.
- Further research is needed to address remaining questions regarding DENV infection in this model.
