Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Criticisms of the Evolutionary Perspective01:23

Criticisms of the Evolutionary Perspective

In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
Limits to Natural Selection01:38

Limits to Natural Selection

Organisms that are well-adapted to their environment are more likely to survive and reproduce. However, natural selection does not lead to perfectly adapted organisms. Several factors constrain natural selection.For one, natural selection can only act upon existing genetic variation. Hypothetically, redtusks may enhance elephant survival by deterring ivory-seeking poachers. However, if there are no gene variants—or alleles—for redtusks, natural selection cannot increase the prevalence of...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Evolutionary Psychology01:20

Evolutionary Psychology

Evolutionary psychology explores the origins of human behavior and mental processes by framing them within the context of natural selection, a theory famously propounded by Charles Darwin. This field asserts that many behaviors common across human societies — ranging from instinctive fear reactions to complex social interactions — arose as evolutionary adaptations. These adaptations enhanced the survival and reproductive success of our ancestors, thereby becoming embedded in the human psyche...
Transduction01:16

Transduction

Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lifetime congenital urologic care: centering patient voices.

Journal of patient-reported outcomes·2026
Same author

Investigating Physical Exercise and Cognitive Training Effects on Cognition and Brain Health in Men and Women with Heart Failure: The ReCARDIO Trial.

CJC open·2026
Same author

Cognition in Chronic Heart Failure: Advancing Knowledge for Better Prevention Through Remote Assessment.

CJC open·2026
Same author

Integrated Genomic and Epigenomic Analysis Reveals Epigenetic Plasticity in Disease Progression and Multidrug Resistance in Multiple Myeloma.

Cancer research·2026
Same author

Cancer Evolvability Determines Therapy Outcomes.

bioRxiv : the preprint server for biology·2026
Same author

Co-induction of stromal and epithelial progenitors for renal regeneration.

Innovation (Cambridge (Mass.))·2026

Related Experiment Video

Updated: Jun 20, 2026

Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants
08:58

Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants

Published on: July 29, 2019

Lessons from applied ecology: cancer control using an evolutionary double bind.

Robert A Gatenby1, Joel Brown, Thomas Vincent

  • 1Departments of Radiology and Integrative Mathematical Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA. Robert.Gatenby@Moffitt.org

Cancer Research
|September 16, 2009
PubMed
Summary
This summary is machine-generated.

Cancer spread is like invasive species. Durable control requires therapies that impose a high fitness cost on cancer cells, creating an evolutionary bind.

More Related Videos

Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation
10:24

Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation

Published on: September 19, 2019

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli
15:00

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli

Published on: August 18, 2023

Related Experiment Videos

Last Updated: Jun 20, 2026

Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants
08:58

Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants

Published on: July 29, 2019

Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation
10:24

Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation

Published on: September 19, 2019

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli
15:00

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli

Published on: August 18, 2023

Area of Science:

  • Evolutionary biology
  • Cancer biology
  • Ecology

Background:

  • Metastatic cascade relies on malignant cells adapting to new environments.
  • Pest control often fails due to evolved resistance, limiting treatment efficacy.

Purpose of the Study:

  • To propose cancer as analogous to invasive species dynamics.
  • To explore the role of phenotypic cost in treatment resistance.

Main Methods:

  • Comparative analysis of cancer metastasis and invasive species ecology.
  • Theoretical framework examining evolutionary and ecological principles.

Main Results:

  • Treatment resistance is not solely determined by resistance evolution, but by its phenotypic cost.
  • Cancer cell adaptation via minor changes (e.g., metabolism) allows continued fitness and proliferation.
  • Significant phenotypic costs associated with resistance can create an 'evolutionary double bind'.

Conclusions:

  • Durable cancer control hinges on inducing costly adaptations that reduce cancer cell fitness.
  • Therapeutic strategies should aim to impose substantial fitness burdens, not just resistance mechanisms.