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Updated: Jun 20, 2026
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Pre-clinical Orthotopic Murine Model of Human Prostate Cancer
Published on: August 29, 2016
Pure primary prostatic osteosarcoma arising in a non-irradiated prostate
Farhang Rabbani1, Ronnie G Fine, David D'Adamo
1Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. rabbanif@mskcc.org
Urologia Internationalis
|September 16, 2009
Summary
This case study details a rare osteogenic sarcoma of the prostate in a 68-year-old male presenting with hematuria. The advanced pelvic tumor required extensive surgical intervention and radiotherapy.
Area of Science:
- Urology
- Oncology
- Surgical Pathology
Background:
- Prostate sarcoma is a rare malignancy.
- Osteogenic features within prostate sarcoma are exceptionally uncommon.
Observation:
- A 68-year-old male presented with hematuria.
- Imaging revealed a locally advanced pelvic mass involving the prostate, seminal vesicles, and rectal wall.
- No distant metastatic disease was identified.
Findings:
- Prostate biopsy confirmed sarcoma with osteogenic features.
- The tumor involved the prostate, seminal vesicles, bladder, rectum, and perirectal tissue.
- Surgical resection involved total pelvic exenteration with intraoperative radiotherapy.
Implications:
- This case highlights the importance of considering rare sarcomas in prostate cancer diagnostics.
- Aggressive surgical and radiotherapeutic approaches may be necessary for locally advanced disease.
- Further research into the pathogenesis and optimal treatment of prostate osteogenic sarcoma is warranted.
