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Early dermato-pathological signs during bath-PUVA therapy.
C Piérard-Franchimont1, D Nickels-Read, T Ben Mosbah
1Department of Dermatopathology, University of Liège, Belgium.
The Journal of Pathology
|July 1, 1990
Summary
Trioxsalen bath and long-wave ultraviolet A (UV-A) therapy for psoriasis causes significant epidermal and dermal changes. Histological examination reveals vacuolar alterations, cell death, and atypical melanocytes, alongside increased factor XIIIa-positive dendrocytes.
Area of Science:
- Dermatology
- Histopathology
- Photochemotherapy
Background:
- Trioxsalen bath combined with long-wave ultraviolet A (UV-A) is a dermatological treatment for psoriasis.
- The clinical side effects of this therapy are known.
- This study focuses on the histological changes induced by this treatment.
Purpose of the Study:
- To describe the histological features of skin lesions resulting from trioxsalen bath and UV-A therapy.
- To detail the epidermal and dermal cellular alterations observed post-treatment.
Main Methods:
- Histological examination of skin lesions from patients treated with trioxsalen bath and UV-A.
- Microscopic analysis of epidermal and dermal cellular morphology and distribution.
Main Results:
- Striking epidermal changes include vacuolar alterations, stratum malpighi disorganization, necrotic cells, and Bowenoid changes.
- Langerhans cells are reduced, and melanocytes may appear large and atypical.
- Factor XIIIa-positive dendrocytes in the superficial dermis enlarge and some migrate into the epidermis.
Conclusions:
- Trioxsalen bath and UV-A therapy induce characteristic histological changes in the epidermis and dermis.
- These changes involve cellular alterations, including atypical melanocytes and migrating dendrocytes.
- Understanding these histological aspects is crucial for interpreting treatment-related skin lesions.