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Updated: Jun 20, 2026

Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
An unidentified monster in the bed--assessing nocturnal asthma in children
1Department of Cellular Biology and Anatomy, Technion-Israel Institute of Technology, Faculty of Medicine Rappaport Building, 7 Rehov Efron, Bat Galim, Haifa, Israel. Ginsberg@tx.technion.ac.il
Insights
Nocturnal asthma (NA) is underdiagnosed in children. An automated wheeze detection device offers an objective, home-based solution for diagnosing and monitoring this condition, improving quality of life.
Area of Science:
- Pediatrics
- Pulmonology
- Sleep Medicine
Background:
- Nocturnal asthma (NA) prevalence is rising globally, impacting millions and decreasing quality of life.
- NA-related sleep disturbances in children cause behavioral and developmental issues.
- Current diagnostic methods like diurnal spirometry are impractical for NA, relying on unreliable self/parental reports.
Purpose of the Study:
- To review the increasing prevalence of nocturnal asthma (NA) in children.
- To discuss current diagnostic challenges and consequences of undiagnosed NA.
- To propose an objective, home-based diagnostic tool for NA in children.
Main Methods:
- Review of existing literature on nocturnal asthma prevalence, diagnosis, and impact.
- Analysis of limitations of current diagnostic tools (spirometry, self/parental reports).
- Exploration of wheeze detection during sleep as a diagnostic marker.
Main Results:
- Nocturnal asthma is chronically underreported due to underestimation by children and lack of parental/physician awareness.
- Existing diagnostic tools are impractical or unreliable for assessing NA in children.
- Wheeze detection during sleep has shown promise as a diagnostic measure for NA.
Conclusions:
- An automated wheeze detection device is proposed as an objective and practical tool for diagnosing and monitoring nocturnal asthma in children.
- This technology could address the underreporting of NA and improve patient outcomes.
- Improved diagnosis and monitoring are crucial for managing NA and mitigating its effects on children's quality of life.
Abstract:
Nocturnal asthma (NA) is increasing in prevalence, affecting millions of people worldwide. In addition to being associated with increased mortality, NA is associated with a decreased quality of life. NA associated sleep disturbances and increased daytime sleepiness are especially important in children due to the accompanying behavioral and developmental difficulties. As diurnal spirometry is not a practical tool for the diagnosis and monitoring of NA, self or parental reports are used. Children underreport and underestimate their NA symptoms and parents are not fully aware of their child's NA indicators. In addition, there is the lack of physician familiarity regarding the assessment and treatment of NA. Therefore, NA is chronically underreported. The development of a non-invasive, objective, home-based diagnostic tool is crucial in diagnosing and monitoring children with NA. The presence of wheeze during sleep has been successfully employed as a tool to measure NA in children. This review discusses the increasing prevalence of NA, current diagnostic tools and the consequences of undiagnosed NA in children. In conclusion, this paper suggests that an automated wheeze detective device is an objective and practical tool to aid the diagnosis and monitoring of NA.
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