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Synthesis and preliminary biological evaluations of [18F]-1-deoxy-1-fluoro-scyllo-inositol
Neil Vasdev1, Jason Chio, Erik M van Oosten
1PET Centre, Centre for Addiction and Mental Health, 250 College St., Toronto, ON, Canada M5T 1R8. neil.vasdev@camhpet.ca
Chemical Communications (Cambridge, England)
|September 16, 2009
Abstract:
A novel PET radiotracer, [18F]-1-deoxy-1-fluoro-scyllo-inositol, was synthesized via a one-pot reaction in 16 +/- 3% uncorrected radiochemical yield within 80 minutes; although this compound revealed low brain penetration it shows promise in rodent tumour models for breast cancer imaging.
