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Acute myocardial infarction in a patient with hemophilia A and factor V Leiden mutation

Meral Günaldi1, Ayşen Helvaci, Naciye Demirel Yildirim

  • 12nd Clinic for Internal Diseases, Okmeydani Education and Research Hospital, Istanbul, Turkey. meralgunaldi@hotmail.com

Cardiology Journal
|September 16, 2009
PubMed

Factor VIII:C, epsilon amino-caproic acid or tranexamic acid are prophylactic agents used in preventing hemorrhage pre-operatively in patients with hemophilia A. Although hemophilia A seems to be a factor that avoids the development of acute myocardial infarction (AMI) as it tends to be associated with increased bleeding, it should be kept in mind that prothrombotic agents used pre-operatively for prophylaxis may increase the risk for AMI in the presence of the factor V Leiden mutation. In this report, we discuss the development of AMI following the use of recombinant factor VIII and tranexamic acid for prophylaxis in a patient with known hemophilia before a tooth extraction in conjunction with the relevant literature.

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