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Chemical avulsion with urea nail lacquer
The Journal of Dermatological Treatment
|September 17, 2009
Summary
A novel 40% urea nail lacquer offers a comfortable and effective method for onychomycosis treatment. This formulation aids in the easy removal of the fungal nail plate, simplifying pathogen eradication.
Area of Science:
- Dermatology
- Mycology
- Pharmacology
Background:
- Onychomycosis treatment presents therapeutic challenges.
- Chemical nail avulsion is a logical strategy for pathogen eradication.
- Novel formulations are needed to improve onychomycosis management.
Purpose of the Study:
- To evaluate a new 40% urea nail lacquer formulation for onychomycosis.
- To assess the efficacy and patient comfort of the urea nail lacquer.
- To determine if the formulation facilitates removal of the diseased nail plate.
Main Methods:
- A formulation containing 40% urea in a film-forming solution was developed.
- Ten patients with onychomycosis were treated with the urea nail lacquer.
- Application involved brushing the lacquer twice daily for one week, with extended use in two patients.
Main Results:
- The urea nail lacquer acts as a transungual delivery system.
- It effectively weakens the nail plate/nail bed attachment in diseased areas.
- This mechanism facilitates the removal of the affected nail portion.
Conclusions:
- The urea nail lacquer provides a comfortable patient experience.
- It enables straightforward removal of the fungal nail plate.
- This approach supports the eradication of the onychomycosis pathogen.
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