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Updated: Jun 20, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
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Published on: May 8, 2015

Cell-targeted self-assembled DNA nanostructures.

Alexey Y Koyfman1, Gary B Braun, Norbert O Reich

  • 1Biomolecular Science and Engineering Program, University of California-Santa Barbara, Santa Barbara, California 93106-9510, USA.

Journal of the American Chemical Society
|September 17, 2009
PubMed
Summary
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We developed two methods to attach DNA nanoarrays to cell surfaces. These strategies enable precise cell labeling, cell scaffolding, and targeted material delivery for biomedical applications.

Area of Science:

  • Biotechnology
  • Nanotechnology
  • Cell Biology

Background:

  • Cell surface engineering is crucial for targeted therapies and diagnostics.
  • Self-assembled DNA structures offer precise nanoscale architecture.
  • Efficient methods for attaching DNA nanoarrays to cells are needed.

Purpose of the Study:

  • To present novel strategies for attaching self-assembled DNA arrays to cell surfaces.
  • To demonstrate the versatility of DNA nanoarrays in cell surface functionalization.
  • To explore applications in cell labeling, scaffolding, and material delivery.

Main Methods:

  • Utilized biotin-streptavidin interactions for attaching DNA arrays to biotinylated cells.
  • Employed antibody-conjugated DNA arrays for specific binding to cell surface receptors (e.g., epidermal growth factor receptors).

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Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
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Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Related Experiment Videos

Last Updated: Jun 20, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

  • Visualized DNA array-cell interactions using fluorescence, confocal, and scanning electron microscopy.

    • Main Results:

    • Successfully attached DNA nanoarrays to cell surfaces using two distinct methods.
    • Demonstrated specific and targeted binding of DNA arrays to cancer cells.
    • Visual evidence confirmed successful array-cell surface conjugation.

    Conclusions:

    • Developed effective strategies for DNA nanoarray immobilization on cell surfaces.
    • Highlighted the potential of DNA nanoarrays for creating patterned cell surfaces.
    • Opened avenues for engineering cell networks, microtissues, and targeted delivery systems.