Related Experiment Video
Updated: Jun 20, 2026

Lumbar Intrathecal Injection of Gene Therapy Vectors for Central Nervous System Targeting in Mice and Rats
Published on: May 16, 2025
Intrathecal baclofen and pregnancy: implications for clinical care
Margo DeVries-Rizzo1, Diny Warren, Gail Delaney
1Children's Hospital, London Health Sciences Centre. margo.devries-rizzo@lhsc.on.ca
Abstract:
Pregnancy in patients with intrathecal baclofen (ITB) pumps is rare. To our knowledge, only five reported cases of pregnancy exist in the literature. Thus, there is little experience to inform health care practitioners about the maternal and fetal safety of ITB or its efficacy throughout pregnancy. There are no reports of a pregnant female with an implanted ITB pump having a spontaneous, vaginal delivery at term. As far as we know, this is the first case described in the literature. Additionally, current literature does not address clinical implications for these patients. This paper reviews literature to date and presents unique aspects of our patient. It also discusses clinical implications for treating a pregnant patient with an ITB pump. The intent of this paper is to advance our body of knowledge in caring for pregnant clients with ITB pumps and reassure families about the safety and efficacy of this treatment.
Related Concept Videos
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Local Anesthetics: Clinical Application as Spinal Anesthesia
Skeletal Muscle Relaxants: Adverse Effects
Unlike...
Skeletal Muscle Relaxants: Therapeutic Uses
Teratogenicity