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Related Experiment Video

Updated: Jun 20, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

IL-18 activity in systemic lupus erythematosus.

Flavia Favilli¹, Consuelo Anzilotti, Lucia Martinelli

¹National Research Council, Institute of Biomedical Technologies, Pisa, Italy. flavia.favilli@itb.cnr.it

Annals of the New York Academy of Sciences

|September 18, 2009

Summary

Interleukin-18 (IL-18), a key inflammation cytokine, is implicated in systemic lupus erythematosus (SLE) pathogenesis. Elevated IL-18 levels correlate with SLE severity and may predict renal damage, suggesting its role in disease progression and potential therapeutic targeting.

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Last Updated: Jun 20, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Area of Science:

Immunology
Autoimmunity
Cytokine Biology

Background:

Interleukin-18 (IL-18) is a crucial cytokine in innate immunity and adaptive Th1 responses.
Increased IL-18 levels are observed in various autoimmune diseases, including systemic lupus erythematosus (SLE).

Purpose of the Study:

To critically review the role of IL-18 in the pathogenesis of SLE.
To examine IL-18 as a potential biomarker for disease severity and renal involvement in SLE.

Main Methods:

Review of existing literature on IL-18 in SLE.
Analysis of studies correlating IL-18 levels with disease activity and renal damage.
Examination of findings from a mouse model of progressive lupus.

Main Results:

Elevated serum/plasma IL-18 levels in SLE patients correlate with disease severity.
IL-18 may serve as a prognostic marker for renal damage and failure risk in SLE.
Urinary IL-18 levels correlate with the degree of renal involvement.
IL-18 changes precede disease development in affected organs in a lupus mouse model.

Conclusions:

IL-18 plays a multifaceted role in SLE, contributing to initial pathogenic events and late organ damage.
IL-18 is implicated in both early and late stages of autoimmune lupus.
Therapeutic strategies targeting IL-18 are being developed for autoimmune conditions.