Biological and molecular variability of human immunodeficiency virus type 2 isolates from The Gambia

¹Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom.

|October 1, 1990

Abstract:

Seven new human immunodeficiency virus type 2 (HIV-2) isolates (CBL-20 to CBL-26) from The Gambia were characterized. Their cytopathogenicity and growth in vitro correlated with the severity of clinical disease. CBL-22 was highly sensitive to neutralization by HIV-2 sera and was cross-neutralized by some HIV-1 sera. These findings, the differing sizes of envelope glycoproteins of individual isolates, and the sequence analysis of amplified regions of the viral DNAs show that these HIV-2 isolates from one geographical region in West Africa exhibit biological and genome variability comparable to that observed for HIV-1.

Keywords:

Africa Africa South Of The Sahara Biology Clinical Research Developing Countries Diseases English Speaking Africa Gambia Hiv Infections Immunity Immunologic Factors In Vitro Physiology Research Methodology Viral Diseases Western Africa

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Abstract:

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