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DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...
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Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
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Published on: February 18, 2016

[Cocaine-triggered ischaemic enteritis].

Lise Hobolth1, Flemming Bendtsen

  • 1Gastroenheden 439, Hvidovre Hospital, DK-2650 Hvidovre. lise.hobolth@hvh.regionh.dk

Ugeskrift for Laeger
|September 18, 2009
PubMed
Summary
This summary is machine-generated.

Recurrent abdominal pain in a young woman was linked to cocaine use, mimicking Crohn's disease. The condition resolved spontaneously, highlighting ischemic enteritis as a potential cause in recreational drug users.

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Area of Science:

  • Gastroenterology
  • Toxicology
  • Internal Medicine

Background:

  • Crohn's disease is a chronic inflammatory bowel disease often presenting with abdominal pain and altered bowel habits.
  • Diagnostic challenges arise when symptoms overlap with other conditions, necessitating a comprehensive patient history.
  • Ischemic enteritis, a rare condition caused by reduced blood flow to the intestine, can manifest with similar symptoms.

Observation:

  • A 25-year-old woman experienced recurrent hospitalizations over five years due to abdominal pain, elevated C-reactive protein (CRP), and leukocytosis.
  • Initial investigations, including ultrasound and small bowel examination, suggested terminal ileum edema, leading to a suspicion of Crohn's disease.
  • Despite negative ileocolonoscopy, biopsy, and capsule endoscopy, the patient's condition consistently normalized spontaneously.

Findings:

  • A detailed patient interview and diary revealed a direct correlation between recreational cocaine use and episodes of abdominal pain.
  • The clinical presentation and resolution pattern were consistent with cocaine-induced ischemic enteritis.
  • Previous literature supports the association between cocaine use and ischemic enteritis.

Implications:

  • This case underscores the importance of considering drug-induced enteritis in the differential diagnosis of inflammatory bowel disease mimics.
  • Thorough patient history, including recreational drug use, is crucial for accurate diagnosis and management.
  • Awareness of cocaine's potential gastrointestinal complications can prevent misdiagnosis and unnecessary treatments.