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Published on: July 8, 2025
Sutureless skin closure with isoamyl 2-cyanoacrylate in pediatric day-care surgery
Zaheer Hasan1, Ajay N Gangopadhyay, Dinesh K Gupta
1Department of Pediatric Surgery, IMS, BHU, Varanasi, India. drzaheerhasan@yahoo.com
Insights
Isoamyl 2-cyanoacrylate offers a promising alternative for pediatric day-care surgery skin closure. This tissue adhesive resulted in improved cosmetic outcomes and no major complications compared to traditional methods.
Area of Science:
- Pediatric Surgery
- Wound Healing
- Biomaterials
Background:
- Day-care surgery is increasingly common for pediatric patients, demanding procedures with minimal complications.
- Tissue adhesives offer potential advantages over sutures, staples, and tapes, including better cosmetic results and reduced infection rates.
Purpose of the Study:
- To evaluate the efficacy and safety of isoamyl 2-cyanoacrylate as a topical skin adhesive for pediatric day-care surgery.
Main Methods:
- Isoamyl 2-cyanoacrylate (Novocryl) was applied to the skin margins of 100 pediatric patients undergoing day-care surgery after subcutaneous tissue closure.
- Skin margins were approximated using skin hooks for 1-2 minutes to allow adhesive polymerization.
Main Results:
- The use of isoamyl 2-cyanoacrylate resulted in superior cosmetic outcomes, with no visible suture marks or lumpiness.
- No major complications were reported in any of the 100 patients during the study period.
Conclusions:
- Isoamyl 2-cyanoacrylate is a safe and effective alternative to traditional skin closure methods in pediatric day-care surgery.
- The tissue adhesive provides excellent cosmetic results and a low complication profile for pediatric wound management.
Abstract:
Importance of day-care surgery in pediatric age group is ever increasing and nowadays bulk of surgery is performed as a day-care procedure. Day-care procedure requires short intra-operative period and less postoperative complications. The introduction of tissue adhesive has been received enthusiastically since they may result in equivalent tensile strength-improved cosmetic appearance of the scar and lower infection rate when compared to sutures, staples and adhesive tape. We have used isoamyl 2-cyanoacrylate as a tissue adhesive for skin closure in day-care surgery. Novocryl is ideal for such procedure as it is a sterile, inert, non-toxic, biocompatible and bacteriostatic liquid topical skin adhesive containing isoamyl 2-cyanoacrylate formulation. We applied isoamyl 2-cyanoacrylate glue in 100 patients over skin cut margin after stitching subcutaneous tissue. Skin margin were held together by means of skin hook for 1-2 min. The cosmesis was better as there were no suture marks or lumpiness. There were no major complications in our study. Thus, isoamyl 2-cyanoacrylate can be considered as an alternative to skin suturing in the pediatric day-care surgery.

