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CD13+ anaplastic large cell lymphoma with leukemic presentation and additional chromosomal abnormality
Suncica Ries1, Lana Rnjak, Zdravko Mitrović
1Department of Pathology and Cytology, University Hospital Center Zagreb, Zagreb 10000, Croatia. sun77ries@yahoo.com
Diagnostic Cytopathology
|September 18, 2009
Summary
Anaplastic large cell lymphoma (ALCL) can present with unusual myeloid markers, challenging diagnosis. Recognizing this rare presentation is crucial for appropriate treatment and prognosis.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Anaplastic large cell lymphoma (ALCL) is a malignant neoplasm with diverse presentations.
- Myeloid-associated markers can complicate ALCL diagnosis, potentially leading to misclassification as myeloid neoplasms.
- Accurate differentiation is vital due to distinct therapeutic strategies and prognoses.
Observation:
- A 16-year-old female presented with fever, lymphadenopathy, and leukocytosis.
- The patient was diagnosed with CD13-positive ALCL exhibiting a leukemic phase.
- A cytogenetic abnormality, duplication 5q35, was identified.
Findings:
- The case highlights a rare CD13-positive ALCL with a leukemic presentation and a specific cytogenetic abnormality.
- This unusual phenotype presents a diagnostic challenge, mimicking myeloid neoplasms.
- The combination of features necessitates careful consideration in differential diagnoses.
Implications:
- This case underscores the importance of considering ALCL in the differential diagnosis of myeloid neoplasms, especially with unusual immunophenotypes.
- Early and accurate diagnosis of such rare ALCL presentations is critical for effective patient management.
- Awareness of this diagnostic challenge can prevent treatment delays and improve patient outcomes.