Related Experiment Video
Updated: Aug 18, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
Published on: April 28, 2016
Gastric somatostatin: a paracrine regulator of acid secretion
1Department of Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0711.
Abstract:
The presence of acid in the lumen of the gastric fundus induces release of somatostatin close to the parietal cells; this acts to attenuate acid secretion in response to secretagogues, such as histamine and gastrin. The release of somatostatin within the stomach is further regulated by the activity of cholinergic neurons that inhibit somatostatin release and thus augment acid secretion (disinhibition), and noncholinergic (bombesin) neurons that stimulate somatostatin release and thus attenuate acid secretion. The influence of these neurons and the participation of somatostatin as a paracrine regulator of acid secretion has been probed and validated by the use of selective antagonists (atropine and a bombesin antagonist), somatostatin antiserum and pertussis toxin. Similar mechanisms exist in the distal antral segment of the stomach for the paracrine regulation of gastrin release by somatostatin.
More Related Videos
09:16Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells
Published on: April 20, 2017
07:00Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
Published on: February 26, 2019
Related Concept Videos
Hormonal Regulation
Stomach pH Regulation
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
Regulation of the Digestive System
The effectors in this regulation system are glands and smooth muscles. Activation of these...
Hormones Secreted by the Stomach
Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples:
Gastric Phase of Digestion
When food enters the stomach, it stretches the stomach walls and activates stretch receptors. This triggers local reflexes of the enteric nervous system, mediated through the myenteric plexus. These...
Mucosal Barrier of the Stomach
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...