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Structure-activity relationship study on alpha1 adrenergic receptor antagonists from beer

Toshiyuki Wakimoto1, Makoto Nitta, Kana Kasahara

  • 1School of Pharmaceutical Sciences, University of Shizuoka and Global COE Program, 52-1 Yada, Suruga-ku, Shizuoka-shi, Shizuoka 422-8526, Japan. wakimoto@u-shizuoka-ken.ac.jp

Bioorganic & Medicinal Chemistry Letters
|September 19, 2009
PubMed
Summary

Researchers determined the absolute stereochemistry of hordatine A and aperidine from beer. The (2R,3R)-hordatine A enantiomer showed the most potent alpha1A adrenoceptor antagonist activity.

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