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Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques
Published on: March 8, 2024
Stigmatellamines A-D: Bacterial Membrane Vesicle-Induced N-Alkylpyridinium Alkaloids from Stigmatella aurantiaca
Teruhisa Manome1, Aya Yoshimura1, Keiko Konuma2
1Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
Abstract:
Four N-alkylpyridinium alkaloids, stigmatellamines A-D (1-4), were isolated from Stigmatella aurantiaca as metabolites induced by membrane vesicles derived from Burkholderia plantarii. Their chemical structures were elucidated through a combination of spectroscopic and synthetic approaches, revealing a unique class of tetrasubstituted N-alkylpyridinium alkaloids. Stigmatellamines A-C exhibited potent cytotoxicity against the human B-cell lymphocytes, RPMI8226. This is the first evidence supporting the ability of B. plantarii MVs to induce cryptic metabolite biosynthesis.
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