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A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice
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Dimethyl sulphoxide dose-response on rat retinal function.

Tina I Tsai1, Bang V Bui, Algis J Vingrys

  • 1Department of Optometry and Vision Sciences, University of Melbourne, Parkville, VIC, 3010, Australia.

Documenta Ophthalmologica. Advances in Ophthalmology
|September 19, 2009
PubMed
Summary
This summary is machine-generated.

Dimethyl sulfoxide (DMSO) affects retinal function in rats at concentrations of 0.6% and higher. Lower doses (≤0.1%) are safe for intravitreal injection, preserving retinal function.

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Toxicology

Background:

  • Dimethyl sulfoxide (DMSO) is a common solvent in laboratory research.
  • Its effects on retinal function following intravitreal injection are not fully understood.

Purpose of the Study:

  • To investigate the impact of varying intravitreal doses of DMSO on retinal function in Long Evans rats.
  • To determine safe concentration limits of DMSO for ocular injections.

Main Methods:

  • Rats received intravitreal injections of DMSO at concentrations ranging from 0.01% to 8%.
  • Retinal function was assessed 1 hour post-injection using electroretinograms (ERGs).
  • ERG waveforms were analyzed to evaluate specific retinal layers: photoreceptors, bipolar cells, and inner retinal neurons.

Main Results:

  • DMSO induced a dose-dependent decrease in retinal function for concentrations ≥0.6%.
  • Photoreceptor function remained unaffected across all tested DMSO doses.
  • Mid-retinal (ON-bipolar) and inner retinal (amacrine and ganglion cells) functions showed significant, dose-dependent impairments.

Conclusions:

  • Intravitreal DMSO concentrations of 0.6% or higher cause short-term retinal dysfunction, primarily affecting bipolar and inner retinal neurons.
  • DMSO concentrations ≤0.1% appear safe for intravitreal use in rat models.
  • These findings provide critical safety guidelines for using DMSO in ocular research.