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Associated Chromosome Trap for Identifying Long-range DNA Interactions

Associated Chromosome Trap for Identifying Long-range DNA Interactions

Published on: April 23, 2011

Haplotype association mapping in mice.

Shirng-Wern Tsaih¹, Ron Korstanje

¹The Jackson Laboratory, Bar Harbor, ME, USA.

Methods in Molecular Biology (Clifton, N.J.)

|September 19, 2009

Summary

Haplotype Association Mapping (HAM) is a novel phenotype-driven method for identifying genetic loci in mice. This approach, similar to human Genome-Wide Association studies, analyzes strain haplotype associations with traits.

Area of Science:

Genetics
Bioinformatics
Animal Models

Background:

Haplotype Association Mapping (HAM) is a phenotype-driven genetic analysis method.
Originally developed for mice, HAM treats inbred strains as individual data points.
It shares similarities with human Genome-Wide Association (GWA) studies.

Purpose of the Study:

To review the current literature on Haplotype Association Mapping.
To present existing methods and applications of HAM.
To offer insights into the future development of HAM.

Main Methods:

HAM identifies genetic loci by associating phenotypes with haplotypes in mouse inbred strains.
The approach treats each inbred strain as an individual unit for analysis.

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It is a phenotype-driven strategy for genetic discovery.

Main Results:

The review covers the current state of Haplotype Association Mapping.
Different methodologies and applications of HAM are presented.
The future trajectory of HAM development is discussed.

Conclusions:

Haplotype Association Mapping is a developing but promising approach for genetic research in mice.
Its phenotype-driven nature and strain-based analysis offer unique advantages.
Continued development is expected to expand its utility in identifying genetic loci.