Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...
Methods of reducing fever01:22

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Diabetes Insipidus II: Pathophysiology01:22

Diabetes Insipidus II: Pathophysiology

Normally, water balance is maintained through three interconnected mechanisms: the hypothalamic thirst center, the synthesis and release of antidiuretic hormone (ADH, or vasopressin), and the kidneys' responsiveness to this hormone. ADH is synthesized in the hypothalamus, released from the posterior pituitary, and acts on the distal nephron, allowing water reabsorption and concentrated urine production.Diabetes Insipidus and Its TypesIn diabetes insipidus (DI), this regulatory system is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coronary artery bypass grafting may not be suitable in pure myocardial bridging: a case report.

European heart journal. Case reports·2026
Same author

Correction to "Integrated Single-Tip IMAC-HILIC Enables Simultaneous Analysis of Plant Phosphoproteomics and N-Glycoproteomics".

Journal of proteome research·2026
Same author

Hyperbaric oxygen protects against periodontal bone loss by modulating inflammation and bone remodeling via RANKL/OPG expression in ligature-induced periodontitis.

International journal of medical sciences·2026
Same author

Single-cell and spatial omics reveal progressive loss of xylem developmental complexity across seed plants.

The Plant cell·2025
Same author

Empowering Gliadin Detection: A Visible-Code Semiquantitative Lateral Flow System for Rapid and Reliable Results.

Journal of agricultural and food chemistry·2025
Same author

Single-cell and spatial multiomics identifies heterogeneous xylem development driven by mechanical stress in Populus.

Developmental cell·2025

Related Experiment Video

Updated: Jun 20, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
08:22

A Preclinical Model of Exertional Heat Stroke in Mice

Published on: July 1, 2021

Decrease of heatstroke-induced multiorgan dysfunction by whole body cooling in streptozotocin-induced diabetic rats.

Chuan-Chih Hsu1, Chiang-Shan Niu, Mao-Tsun Lin

  • 1Division of Cardiovascular Surgery, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan, Republic of China.

The Chinese Journal of Physiology
|September 22, 2009
PubMed
Summary
This summary is machine-generated.

Whole body cooling (WBC) significantly improved survival in diabetic rats experiencing heatstroke. WBC also reduced multiorgan dysfunction, including cerebrovascular, renal, and hepatic damage, by decreasing harmful inflammatory markers.

More Related Videos

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

Prevention of Heat Stress Adverse Effects in Rats by Bacillus subtilis Strain
07:57

Prevention of Heat Stress Adverse Effects in Rats by Bacillus subtilis Strain

Published on: July 11, 2016

Related Experiment Videos

Last Updated: Jun 20, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
08:22

A Preclinical Model of Exertional Heat Stroke in Mice

Published on: July 1, 2021

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

Prevention of Heat Stress Adverse Effects in Rats by Bacillus subtilis Strain
07:57

Prevention of Heat Stress Adverse Effects in Rats by Bacillus subtilis Strain

Published on: July 11, 2016

Area of Science:

  • Physiology
  • Toxicology
  • Endocrinology

Background:

  • Heatstroke poses a significant risk for multiorgan dysfunction, particularly in individuals with pre-existing conditions like diabetes.
  • Streptozotocin (STZ)-induced diabetes in rats serves as a model to study the complex physiological responses to heat stress.
  • Understanding the impact of heatstroke on organ systems is crucial for developing effective therapeutic interventions.

Purpose of the Study:

  • To evaluate the efficacy of whole body cooling (WBC) in mitigating multiorgan dysfunction during heatstroke in diabetic rats.
  • To investigate the physiological and biochemical changes associated with heatstroke in STZ-induced diabetic rats.
  • To assess the impact of WBC on survival rates and specific organ system functions post-heatstroke.

Main Methods:

  • Rats were induced with diabetes using streptozotocin (STZ) and subsequently exposed to a high ambient temperature (43°C) for 58 minutes to induce heatstroke.
  • Four experimental groups were established: normal control, diabetic control, diabetic heatstroke, and diabetic heatstroke with WBC.
  • Measurements included survival time, body temperature, intracranial pressure, serum markers (nitric oxide metabolites, TNF-α, IL-10), renal function (BUN, creatinine), and hepatic enzymes (ALT, AST, ALP).

Main Results:

  • Diabetic heatstroke rats exhibited significantly reduced survival times (11-13 min) compared to controls.
  • Whole body cooling (WBC) dramatically increased survival rates in diabetic heatstroke rats (221-257 min).
  • WBC treatment attenuated heatstroke-induced increases in body temperature, intracranial pressure, and serum inflammatory markers (nitric oxide metabolites, TNF-α, dihydroxybenzoic acid), while improving renal and hepatic function markers.

Conclusions:

  • Whole body cooling is a highly effective intervention for improving survival and mitigating multiorgan dysfunction in STZ-induced diabetic rats experiencing heatstroke.
  • WBC helps to normalize physiological parameters and reduce the levels of detrimental inflammatory mediators associated with heatstroke in this diabetic model.
  • The findings suggest that WBC can be a valuable therapeutic strategy for managing heatstroke-related complications in diabetic individuals.