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Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Radiosurgery for large-volume (> 10 cm3) benign meningiomas
Jonathan M Bledsoe1, Michael J Link, Scott L Stafford
1Department of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
Journal of Neurosurgery
|September 22, 2009
Summary
Stereotactic radiosurgery (SRS) for large intracranial meningiomas (>10 cm3) shows high tumor control but increased complications, especially for supratentorial tumors. Resection is preferred for large supratentorial meningiomas.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Stereotactic radiosurgery (SRS) is a recognized treatment for intracranial meningiomas.
- Morbidity of SRS for larger meningiomas (>10 cm3) requires further understanding.
Purpose of the Study:
- To evaluate the safety and efficacy of SRS for large (WHO Grade I) intracranial meningiomas.
- To compare complication rates between supratentorial and skull base tumors.
Main Methods:
- Retrospective review of 116 patients with meningiomas > 10 cm3 treated with SRS (1990-2007).
- Exclusion of atypical/malignant tumors and prior radiotherapy.
- Minimum 12-month follow-up.
Main Results:
- Tumor control rates of 99% at 3 years and 92% at 7 years.
- 23% complication rate (27/116 patients), including seizures, hemiparesis, trigeminal injury.
- Higher complication rate for supratentorial tumors (44%) vs. skull base tumors (18%).
Conclusions:
- SRS for large meningiomas (>10 cm3) has higher morbidity for supratentorial locations.
- SRS is relatively safe for large skull base meningiomas.
- Surgical resection should be primary for most large supratentorial meningiomas.
