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Updated: Jun 20, 2026

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
Published on: January 29, 2018
[Extranuclear functions of protein sumoylation in the central nervous system]
1Institut de neuromédecine moléculaire, Institut de pharmacologie moléculaire et cellulaire, Centre national de la recherche scientifique, UMR 6097, Université de Nice Sophia-Antipolis, 660, route des Lucioles, Sophia-Antipolis, 06560 Valbonne, France. smartin@in2m.cnrs.fr
Abstract:
Post-translational protein modifications play essential roles in many aspects of cellular functions and therefore in the maintenance of cell integrity. These protein modifications are involved at all stages of neuronal communication within the central nervous system. Sumoylation is a reversible post-translational protein modification that consists in the covalent labelling of a small protein called SUMO to lysine residues of selected target proteins. Sumoylation is a well characterized regulator of nuclear functions and has recently emerged as a key factor for numerous extranuclear processes. Furthermore, sumoylation has recently been shown to modulate synaptic transmission and is also implicated in a wide range of neurodegenerative diseases.
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