Genitourinary tumor following kidney transplantation: a multicenter study
B Einollahi1, N Simforoosh, M Lessan-Pezeshki
1Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. behzad.einollahi@gmail.com
Transplantation Proceedings
|September 22, 2009
Summary
Kidney transplant recipients have a risk of developing genitourinary cancers, with transitional cell carcinoma of the bladder being the most common. This study analyzed cancer incidence in Iranian kidney transplant patients.
Area of Science:
- Nephrology
- Oncology
- Transplantation Medicine
Background:
- Renal transplantation is a primary treatment for end-stage renal disease.
- Immunosuppression post-transplant increases cancer risk in recipients.
- Limited data exists on cancer incidence in transplant populations compared to the general population.
Purpose of the Study:
- To investigate the prevalence, types, and outcomes of genitourinary cancers in Iranian kidney transplant recipients.
- To identify specific cancer types and demographic patterns following kidney transplantation.
Main Methods:
- Retrospective data collection from 5 Iranian kidney transplant centers (1984-2008).
- Inclusion of histologically confirmed tumors diagnosed after kidney transplantation.
- Analysis of 5532 kidney transplant cases.
Main Results:
- Genitourinary tumors were detected in 21 patients (0.38%).
- Transitional cell carcinoma (TCC) of the bladder was the most frequent (n=7), followed by renal cell carcinoma (RCC; n=5).
- TCC of the bladder and RCC showed a male predominance.
Conclusions:
- Transitional cell carcinoma of the bladder is the most common genitourinary malignancy after kidney transplantation in this cohort.
- Early detection and monitoring for genitourinary cancers are crucial in kidney transplant recipients.
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